Metatypical basal cell carcinoma: a clinical review

Background. Metatypical cell carcinoma can be considered as a new entity of skin cancer, being an intermediate typology between basal cell carcinomas and squamous cell carcinomas. The behaviour of the metatypical cell carcinoma lies between these two varieties of skin cancer. It is difficult to perform a differential diagnosis based on morphological and clinical features - therefore it is only possible by accurate histology. Methods. The authors have retrospectively analysed clinical records of 240 patients who were affected by metatypical skin cancer and who were treated by surgery, radiotherapy and chemotherapy. Results. MTC affected more males than females (62.5% vs 37.5%) than males. The most affected site was the cervicofacial area, 71.7%; then the trunk, 10%; the limbs, 9.6%; the scalp 3.7%; and other regions 5%. A recurrence occurred in 24 cases (10%), mainly in head and neck area. Conclusion. In this manuscript, the authors have emphasised the importance of conducting a differential diagnosis, and the importance of the specific treatment for metatypical skin cancer, even though more clinical studies and long-term follow-ups are required before establishing specific guidelines. © 2008 Tarallo et al; licensee BioMed Central Ltd

Implementing joux-vitse’s crossbred algorithm for solving MQ Systems over F\u3csub\u3e2\u3c/sub\u3eon GPUs

\u3cp\u3eThe hardness of solving multivariate quadratic (MQ) systems is the underlying problem for multivariate-based schemes in the field of post-quantum cryptography. The concrete, practical hardness of this problem needs to be measured by state-of-the-art algorithms and high-performance implementations. We describe, implement, and evaluate an adaption of the Crossbred algorithm by Joux and Vitse from 2017 for solving MQ systems over F\u3csub\u3e2\u3c/sub\u3e. Our adapted algorithm is highly parallelizable and is suitable for solving MQ systems on GPU architectures. Our implementation is able to solve an MQ system of 134 equations in 67 variables in 98.39 hours using one single commercial Nvidia GTX 980 graphics card, while the original Joux-Vitse algorithm requires 6200 CPU-hours for the same problem size. We used our implementation to solve all the Fukuoka Type-I MQ challenges for n ∈ {55,…74}. Based on our implementation, we estimate that the expected computation time for solving an MQ system of 80 equations in 84 variables is about one year using a cluster of 3600 GTX 980 graphics cards. These parameters have been proposed for 80-bit security by, e.g., Sakumoto, Shirai, and Hiwatari at Crypto 2011.\u3c/p\u3

FSBday : Implementing Wagner's generalized birthday attack against the SHA-3 round-1 candidate FSB

The hash function FSB is one of the candidates submitted to NIST’s competition to find the new standard hash function, SHA-3. The compression function of FSB is based on error correcting codes. In this paper we show how to use Wagner’s generalized birthday attack to find collisions in FSB’s compression function. In particular, we present details on our implementation attacking FSB48, a toy version of FSB which was proposed by the FSB submitters as a training case for FSB. Our attack does not make use of any properties of the particular linear code used within FSB. FSB48 was chosen as a target where generalized birthday attacks would be one of the strongest attacks and which could be attacked in practice. We show how to adapt this attack so that it runs on our computer cluster of only 10 PCs which provides far less memory than the usual implementation of generalized birthday attacks would require. This situation is very interesting for estimating the security of systems against distributed attacks using contributed off-the-shelf PCs. For the SHA-3 competition this result is meaningful in that it allows to assess the security of FSB against the strongest non-structural attack; it does not provide any insight in the security of this particular choice of linear code

Comparative analysis of nasal and oral mucosa dendritic cells.

Contains fulltext : 50576.pdf (publisher's version ) (Closed access)BACKGROUND: Mucosal dendritic cells (DC) play a crucial role in tolerance induction as seen in mucosal immunotherapy of atopic diseases. Nevertheless little is known about the phenotypical differences of oral and nasal mucosal DC (nmDC). Recently, we could show that oral mucosal myeloid CD1a(+) DC (omDC) differ from their skin counterparts especially by the expression of high affinity receptor for immunoglobulin E (IgE; FcepsilonRI). However, expression pattern of FcepsilonRI and phenotypical characteristics of CD1a(+) nmDC have not been elucidated in detailed yet. METHODS: We performed detailed phenotypical comparison of nmDC and omDC of atopic and nonatopic individuals. RESULTS: As reported for omDC, FcepsilonRI on nmDC of atopic donors was elevated and mostly occupied by IgE while FcepsilonRI was present only in low amounts on nmDC of nonatopic donors. Nevertheless, the highest FcepsilonRI expression has been observed on omDC. Furthermore, significant amounts of costimulatory molecules CD40, CD80 and CD86 could be detected on nmDC that expressed more CD80 compared with omDC. Moreover, nmDC displayed less major histocompatability complex (MHC) class I and II molecules than omDC. In addition, nmDC expressed more C-type lectins CD205, CD206 as well as myeloid marker CD11b while omDC displayed increased expression of CD207 and lipopolysaccharide (LPS) receptor CD14. CONCLUSION: Together these data imply that nmDC phenotypical differ from omDC which might result in diverse functional properties and might be of relevance for selecting routes for immunotherapy of atopic diseases. Moreover these data provide a basis for further studies investigating immunological mechanisms underlying mucosal immunotherapy

Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells.

Item does not contain fulltextBACKGROUND: Despite high bacterial colonization, acute infections are rare in the oral mucosa, implicating tolerogenic predominance. Bacterial antigens like LPSs are recognized by innate immunity receptors such as Toll-like receptor 4 (TLR4), associated with LPS receptor (CD14). OBJECTIVES: Toll-like receptor 4 agonist monosphoryl lipid A has been successfully used as adjuvant in subcutaneous immunotherapy, suggesting reinforcement of allergen-specific tolerance. Recently sublingual immunotherapy (SLIT) has been shown to be an effective alternative to subcutaneous immunotherapy. We observed CD14 expression on human oral Langerhans cells (oLCs), representing a major target of SLIT. However, not much is known about TLR4 expression and its effect on oLCs. METHODS: Cell suspensions were obtained by trypsinization of human oral mucosa and analyzed by flow cytometry, RT-PCR, cytometric bead arrays, ELISA, and mixed lymphocyte reactions. RESULTS: We could show that oLCs express TLR4, and its ligation by monosphoryl lipid A upregulated expression of coinhibitory molecules B7-H1 and B7-H3 while surface expression of costimulatory molecule CD86 was concomitantly decreased. Furthermore, TLR4 ligation on oLCs increased their release of the anti-inflammatory cytokine IL-10 and decreased their stimulatory capacity toward T cells. Moreover, TLR4-ligation on oLCs induced IL-10, TGF-beta1, Forkhead box protein 3, IFN-gamma, and IL-2 production in T cells. CONCLUSION: In view of these data, TLR4-ligation on oLCs might not only play a role in pathogen recognition for efficient immunity but also contribute to the tolerogenic state predominating in the oral cavity